Blockade of voltage-gated K+ currents in rat mesenteric arterial smooth muscle cells by MK801
نویسندگان
چکیده
منابع مشابه
Anorexic effect of K+ channel blockade in mesenteric arterial smooth muscle and intestinal epithelial cells.
Activity of voltage-gated K+ (Kv) channels controls membrane potential (E(m)). Membrane depolarization due to blockade of K+ channels in mesenteric artery smooth muscle cells (MASMC) should increase cytoplasmic free Ca2+ concentration ([Ca2+]cyt) and cause vasoconstriction, which may subsequently reduce the mesenteric blood flow and inhibit the transportation of absorbed nutrients to the liver ...
متن کاملAngiotensin II inhibits and alters kinetics of voltage-gated K(+) channels of rat arterial smooth muscle.
The vasoconstrictor angiotensin II (ANG II) inhibits several types of K(+) channels. We examined the inhibitory mechanism of ANG II on voltage-gated K(+) (K(V)) currents (I(K(V))) recorded from isolated rat arterial smooth muscle using patch-clamp techniques. Application of 100 nM ANG II accelerated the activation of I(K(V)) but also caused inactivation. These effects were abolished by the AT(1...
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Functional closure of the human ductus arteriosus (DA) is initiated within minutes of birth by O2 constriction. It occurs by an incompletely understood mechanism that is intrinsic to the DA smooth muscle cell (DASMC). We hypothesized that O2 alters the function of an O2 sensor (the mitochondrial electron transport chain, ETC) thereby increasing production of a diffusible redox-mediator (H2O2), ...
متن کاملPathophysiology of voltage-gated K+ channels in vascular smooth muscle cells: modulation by protein kinases.
In this review, the pathological alteration and clinical relevance of voltage-gated K(+) (Kv) channels and their specific regulation by protein kinase-dependent signaling in vascular smooth muscle cells are described, particularly focusing on the pulmonary vasculature. The physiological relevance, channel characteristics, pharmacological modulation, and expression of Kv channels vary between di...
متن کاملTTX-sensitive voltage-gated Na+ channels are expressed in mesenteric artery smooth muscle cells.
The presence and properties of voltage-gated Na+ channels in mesenteric artery smooth muscle cells (SMCs) were studied using whole cell patch-clamp recording. SMCs from mouse and rat mesenteric arteries were enzymatically dissociated using two dissociation protocols with different enzyme combinations. Na+ and Ca2+ channel currents were present in myocytes isolated with collagenase and elastase....
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ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2015
ISSN: 1347-8613
DOI: 10.1016/j.jphs.2014.11.005